In Path of Exile 2, endgame progression is all about efficiently tackling content while optimizing your build and Path of Exile 2 Currency gear. Here are some key tips to help you progress through the endgame and maximize your loot and experience:

1. Start with Lower-Tier Maps
If you’re new to the endgame or have just reached it, it’s a good idea to start with lower-tier maps. These are less difficult and give you the chance to get used to the mechanics of mapping, dealing with mods, and managing map resources like currency and crafting materials.

Focus on map completion: Initially, you’ll want to complete as many maps as possible to fill out your Atlas and unlock better content. Some maps may even drop higher-tier items and gear as you progress.

Farming for Resources: Lower-tier maps are also great for farming early resources, such as Orbs of Alchemy, currency, and crafting materials, which will be valuable for crafting better gear as you push into higher-tier maps.

2. Optimize Your Build for Map Farming
Your endgame build should be efficient at clearing maps quickly and safely. Focus on builds that offer strong clear speed and survivability, as this is essential for farming high-tier maps.

Clear Speed vs. Bossing: If you’re planning to farm maps, prioritize clear speed. For bossing, you might need to adjust your build to focus on more single-target damage and survivability.

Use Efficient Skill Gems: Choose skill gems that are known for high damage output and efficient map clearing. Popular skills like Cyclone, Spectral Throw, or Blade Vortex are great for farming since they can quickly clear packs of enemies.

Defensive Layers: In the endgame, you’ll encounter dangerous enemies and bosses. Make sure your build includes layers of defense, such as high resistances, life or energy shield, and defensive buffs (like Fortify or Onslaught).

3. Invest in Map Mods and Rerolls
Maps have modifiers that can either increase their difficulty or provide more rewards. Here’s how to handle them:

Map Mods: Use Orb of Transmutation, Orb of Alchemy, or Chaos Orbs to reroll map mods and get favorable ones. Some mods increase monster density or item rarity, which can make the map run more rewarding. Avoid mods that severely increase difficulty unless you’re well-prepared.

Rerolling: Use Orb of Scouring to remove unwanted modifiers or Vaal Orbs for more chaotic rerolls. Sometimes, it’s worth gambling with these orbs if you’re looking for rare affixes.

Tier Up: When you get high-tier maps, make sure to upgrade them to higher versions with items like Vaal Orbs or use Essences to add more powerful mods that are useful for endgame farming.

4. Efficiently Use Waystones
Waystones are key to accessing higher-level regions in the Atlas. Unlock them as you go, and use them wisely.

Upgrade Waystones: As you gain access to more Waystones, try to upgrade them for faster travel and improved access to higher-tier regions. This will make accessing and clearing harder maps much easier.

Plan Your Routes: Efficient waystone use is all about mapping out your path. When you unlock a new region, look for high-tier map areas that offer good rewards or challenges and plan your route accordingly to minimize wasted travel time.

5. Focus on Atlas Completion
Completing the Atlas is one of the primary objectives in the endgame. Unlocking regions, defeating bosses, and filling out the Atlas gives significant rewards.

Influences and Bosses: As you progress, focus on defeating the Atlas bosses. These bosses drop powerful loot, including unique items and crafting materials that will help you prepare for even more difficult content.

Atlas Passive Tree: Spend time working on your Atlas Passive Tree. The nodes you unlock here can improve your map farming efficiency, unlock additional boss fights, and provide valuable resources like extra loot or better currency drops.

6. Prepare for Uber Bosses
Endgame bosses in PoE 2 are extremely challenging, and you’ll need to be prepared for them. These “Uber” bosses are designed for experienced players and require optimized builds and gear.

Defensive Preparation: Uber bosses can kill you very quickly, so defensive preparation is key. Max out your resistances, use defensive flasks like Quartz Flasks or Granite Flasks, and make sure your life pool is high enough to withstand heavy hits.

Offensive Power: While defensive layers are necessary, you also need the ability to deal significant damage. Consider gearing for high DPS and using the best possible gear and skill gems to ensure you can kill bosses before they overwhelm you with mechanics.

Boss Mechanics: Learn the mechanics of each Uber boss. Some bosses have very specific attack patterns or environmental hazards. Watching guides or practicing these fights can make a huge difference.

7. Crafting and Loot
One of the most exciting parts of PoE’s endgame is the ability to craft powerful gear and loot.

Invest in Crafting Materials: As you explore the Atlas, collect crafting materials like Essences, Fossils, Altering Orbs, and others. These materials will help you improve your gear and craft high-tier items that you can use for yourself or sell for profit.

Upgrade Gear with Orbs: Use orbs like Vaal Orbs, Orb of Fusing, or Exalted Orbs to upgrade your items. Look for items with high potential and roll them to maximize their stats, especially for rare or unique items.

8. Farm Specific Content
Certain types of content in the endgame reward you with unique items, currency, and loot. It’s useful to specialize in farming some of these if you want to maximize your loot.

Labyrinth: The Labyrinth is a great place to farm for Ascendancy points, and completing it provides useful endgame rewards, including powerful enchantments for your gear.

Delve: The Delve system allows you to explore an infinite, procedurally generated mine. You can find valuable crafting materials, rare items, and delve-specific loot here.

Breach Abyss: These are special types of content that offer unique challenges and rewards. Completing Breach or Abyss encounters can net you valuable currency, items, and even highly sought-after uniques.

9. Experiment with Leagues
Leagues in PoE 2 offer unique challenges and mechanics, and they’re often the primary source of new content.

Leagues: Participate in new leagues as they release to experience new mechanics, earn exclusive rewards, and gather special loot. Leagues often offer fresh challenges that make the game feel new.

Leaguestones and Challenges: Use leaguestones to activate special modifiers in maps, which can help you gather more loot or face new bosses and mechanics.

10. Trade and Economy
The economy is a huge part of PoE, and knowing how to trade efficiently can greatly enhance your progression.

Flipping Items: Learn how to flip items to make currency. Pay attention to what items are in demand (like high-tier uniques, high-quality gear, or crafting materials) and use that information to profit.

Currency Farming: Currency is key to crafting and upgrading gear, so make sure to efficiently farm currency. Focus on farming the most profitable content, like high-tier maps, or farm specific areas with good drop rates for currency.

By following these tips, you'll be able to Path of Exile 2 Currency for sale progress through the endgame efficiently and enjoy all that Path of Exile 2 has to offer!